Experiencing frequent headaches after taking melatonin may be a sign that you’re consuming too much of the supplement. Melatonin’s role in regulating circadian rhythms and sleep-wake cycles can affect blood vessel dilation and contribute to headaches in some individuals.

Experiencing frequent headaches after taking melatonin may be a sign that you’re consuming too much of the supplement. Melatonin’s role in regulating circadian rhythms and sleep-wake cycles can affect blood vessel dilation and contribute to headaches in some individuals.